Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC044
Test administered by neuromedic@manusdevices.net
Test date and time 2022-08-11 17:30
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment

old patient

tblMADOPAR 250mg 3x 1/4 caps Madopar 125mg 1x1

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 32 individuals with a value less than 0.64 were subsequently diagnosed with PD. That is, 76.19% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.64 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 17, 'TN': 12, 'TP': 25, 'FP': 18}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 4, 'TN': 5, 'TP': 38, 'FP': 25}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 33, 'TN': 28, 'TP': 9, 'FP': 2}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 9, 'TN': 5, 'TP': 33, 'FP': 25}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 21.584
timePerCircleCoV 0.142863
timePerCircleSlope -0.0212054
meanError 1.64208
tremorFreq 6.05469
tremorRelPower 34.1991
tremorGyroAmpMean 0.0132302
tremorGyroAmpSlope 0.00223257
tremorGyroAmpCoV 0.421069
tremorCoordAmpMean 0.0366439
tremorCoordAmpSlope 0.00244527
tremorCoordAmpCoV 0.358696
tremorAccAmpMean 0.0364556
tremorAccAmpSlope 0.00134436
tremorAccAmpCoV 0.243185
tremorPcRelVar 0.701038
tremorPcX -0.227493
tremorPcY 0.97378

Circle Segment 1

Duration 25.76 s, Accuracy Estimate 1.686 (lower is better)

Circle Segment 2

Duration 19.96 s, Accuracy Estimate 1.428 (lower is better)

Circle Segment 3

Duration 21.4 s, Accuracy Estimate 1.46 (lower is better)

Circle Segment 4

Duration 20.88 s, Accuracy Estimate 1.504 (lower is better)

Circle Segment 5

Duration 20.92 s, Accuracy Estimate 1.496 (lower is better)

Circle Segment 6

Duration 26.8 s, Accuracy Estimate 1.425 (lower is better)

Circle Segment 7

Duration 23.24 s, Accuracy Estimate 1.471 (lower is better)

Circle Segment 8

Duration 21.96 s, Accuracy Estimate 1.947 (lower is better)

Circle Segment 9

Duration 17.0 s, Accuracy Estimate 1.497 (lower is better)

Circle Segment 10

Duration 17.92 s, Accuracy Estimate 2.507 (lower is better)

Spiral

numSpirals 5
timePerSpiralMean 54.584
timePerSpiralCoV 0.180978
timePerSpiralSlope -0.0480727
meanError 2.94739
tremorFreq 6.05469
tremorRelPower 26.9059
tremorGyroAmpMean 0.02586
tremorGyroAmpSlope 0.000309692
tremorGyroAmpCoV 0.448591
tremorCoordAmpMean 0.0422126
tremorCoordAmpSlope 0.000389324
tremorCoordAmpCoV 0.43083
tremorAccAmpMean 0.0424527
tremorAccAmpSlope 0.000277207
tremorAccAmpCoV 0.348266
tremorPcRelVar 0.746406
tremorPcX 0.169354
tremorPcY -0.985555

Spiral Segment 1

Duration 65.96 s, Accuracy Estimate 3.438 (lower is better)

Spiral Segment 2

Duration 48.8 s, Accuracy Estimate 2.024 (lower is better)

Spiral Segment 3

Duration 48.64 s, Accuracy Estimate 2.329 (lower is better)

Spiral Segment 4

Duration 64.56 s, Accuracy Estimate 3.184 (lower is better)

Spiral Segment 5

Duration 44.96 s, Accuracy Estimate 3.762 (lower is better)

Elel

eDurationMean 0.679231
eDurationStd 0.157945
eDurationStdnorm 0.232536
eDurationMedian 0.655
eDurationQuartdelta 0.20375
eDurationQuartdeltanorm 0.311069
eDurationKurt 3.88861
eDurationTrenddiff -0.125
eDurationTrendratio 0.817518
eWidthMean 3.684
eWidthStd 1.01782
eWidthStdnorm 0.27628
eWidthMedian 3.393
eWidthQuartdelta 1.4625
eWidthQuartdeltanorm 0.431034
eWidthKurt 5.56926
eWidthTrenddiff 0.936
eWidthTrendratio 1.30769
eHeightMean 8.868
eHeightStd 1.79582
eHeightStdnorm 0.202506
eHeightMedian 8.775
eHeightQuartdelta 2.42775
eHeightQuartdeltanorm 0.276667
eHeightKurt 6.1094
eHeightTrenddiff 1.638
eHeightTrendratio 1.19718
eAspectMean 0.429167
eAspectStd 0.138473
eAspectStdnorm 0.322656
eAspectMedian 0.396825
eAspectQuartdelta 0.101939
eAspectQuartdeltanorm 0.256885
eAspectKurt 15.7195
eAspectTrenddiff 0.0497835
eAspectTrendratio 1.13143
eSlantMean 0.0385523
eSlantStd 0.17477
eSlantStdnorm 4.53334
eSlantMedian 0.016129
eSlantQuartdelta 0.156284
eSlantQuartdeltanorm 9.68963
eSlantKurt 12.5845
eSlantTrenddiff 0.0757881
eRtopMean 0.751914
eRtopStd 0.141741
eRtopStdnorm 0.188507
eRtopMedian 0.785714
eRtopQuartdelta 0.216498
eRtopQuartdeltanorm 0.275543
eRtopKurt 2.50903
eRtopTrenddiff 0.0198413
eRbotMean 0.700765
eRbotStd 0.270407
eRbotStdnorm 0.385874
eRbotMedian 0.7
eRbotQuartdelta 0.291351
eRbotQuartdeltanorm 0.416215
eRbotKurt 3.99929
eRbotTrenddiff -0.103668
eRrightMean 0.848045
eRrightStd 0.11449
eRrightStdnorm 0.135005
eRrightMedian 0.870968
eRrightQuartdelta 0.102606
eRrightQuartdeltanorm 0.117807
eRrightKurt 5.79231
eRrightTrenddiff 0.032967
eRleftMean 0.455945
eRleftStd 0.150303
eRleftStdnorm 0.329652
eRleftMedian 0.5
eRleftQuartdelta 0.239978
eRleftQuartdeltanorm 0.479957
eRleftKurt 2.81417
eRleftTrenddiff -0.136951
lDurationMean 1.10847
lDurationStd 0.210156
lDurationStdnorm 0.18959
lDurationMedian 1.12
lDurationQuartdelta 0.31
lDurationQuartdeltanorm 0.276786
lDurationKurt 2.18552
lDurationTrenddiff -0.16
lDurationTrendratio 0.865828
lWidthMean 5.00175
lWidthStd 1.5261
lWidthStdnorm 0.305114
lWidthMedian 4.68
lWidthQuartdelta 1.638
lWidthQuartdeltanorm 0.35
lWidthKurt 5.09824
lWidthTrenddiff 0.117
lWidthTrendratio 1.02532
lHeightMean 19.3863
lHeightStd 2.67179
lHeightStdnorm 0.137819
lHeightMedian 19.422
lHeightQuartdelta 2.925
lHeightQuartdeltanorm 0.150602
lHeightKurt 3.11669
lHeightTrenddiff 1.521
lHeightTrendratio 1.08202
lAspectMean 0.262274
lAspectStd 0.0990563
lAspectStdnorm 0.377683
lAspectMedian 0.233806
lAspectQuartdelta 0.0945985
lAspectQuartdeltanorm 0.404603
lAspectKurt 17.1382
lAspectTrenddiff -0.0111263
lAspectTrendratio 0.953355
lSlantMean 0.0349419
lSlantStd 0.100239
lSlantStdnorm 2.86872
lSlantMedian 0.0426008
lSlantQuartdelta 0.114812
lSlantQuartdeltanorm 2.69506
lSlantKurt 4.3337
lSlantTrenddiff 0.0503207
lRtopMean 0.7811
lRtopStd 0.137001
lRtopStdnorm 0.175395
lRtopMedian 0.791182
lRtopQuartdelta 0.17805
lRtopQuartdeltanorm 0.225043
lRtopKurt 2.34118
lRtopTrenddiff 0.0253887
lRbotMean 0.686717
lRbotStd 0.386591
lRbotStdnorm 0.562956
lRbotMedian 0.613821
lRbotQuartdelta 0.442817
lRbotQuartdeltanorm 0.72141
lRbotKurt 6.74737
lRbotTrenddiff -0.141493
lRrightMean 0.885285
lRrightStd 0.0844948
lRrightStdnorm 0.0954437
lRrightMedian 0.91239
lRrightQuartdelta 0.128102
lRrightQuartdeltanorm 0.140403
lRrightKurt 2.49692
lRrightTrenddiff 0.0269002
lRleftMean 0.312827
lRleftStd 0.121141
lRleftStdnorm 0.387245
lRleftMedian 0.289416
lRleftQuartdelta 0.158673
lRleftQuartdeltanorm 0.548253
lRleftKurt 2.25495
lRleftTrenddiff 0.0500757

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

FITTS Short Modified

meanTouchScore 0.799455
sumTouchScores 7.99455
meanMovementTime 1.87111
numTouches 10
undershootPercentage 0
overshootPercentage 20

FITTS Long Modified

meanTouchScore 0.752625
sumTouchScores 9.78412
meanMovementTime 1.65333
numTouches 13
undershootPercentage 15.3846
overshootPercentage 23.0769

ZigZag

numZigzags 5
timePerZigzagMean 43.944
timePerZigzagCoV 0.0686004
timePerZigzagSlope -0.00273075
meanError 2.05088
tremorFreq 5.76172
tremorRelPower 40.4383
tremorGyroAmpMean 0.0244459
tremorGyroAmpSlope 0.000203343
tremorGyroAmpCoV 0.43668
tremorCoordAmpMean 0.0506217
tremorCoordAmpSlope 0.000299632
tremorCoordAmpCoV 0.369973
tremorAccAmpMean 0.0947634
tremorAccAmpSlope 6.46662e-05
tremorAccAmpCoV 0.0909943
tremorPcRelVar 0.716321
tremorPcX 0.201888
tremorPcY 0.979409

ZigZag Segment 1

Duration 41.36 s, Accuracy Estimate 2.232 (lower is better)

ZigZag Segment 2

Duration 46.88 s, Accuracy Estimate 1.95 (lower is better)

ZigZag Segment 3

Duration 43.72 s, Accuracy Estimate 1.735 (lower is better)

ZigZag Segment 4

Duration 47.12 s, Accuracy Estimate 1.774 (lower is better)

ZigZag Segment 5

Duration 40.64 s, Accuracy Estimate 2.563 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 27.96
timePerZigzagCoV 0.114127
timePerZigzagSlope -0.055794
zigzagHeightMean 80.803
zigzagHeightCoV 0.0922983
zigzagHeightSlope 0.0486331
meanError 0.0426799
tremorFreq 6.15234
tremorRelPower 26.6692
tremorGyroAmpMean 0.01817
tremorGyroAmpSlope 0.00165002
tremorGyroAmpCoV 0.344156
tremorCoordAmpMean 0.0492785
tremorCoordAmpSlope 0.00160107
tremorCoordAmpCoV 0.353011
tremorAccAmpMean 0.0753763
tremorAccAmpSlope 0.000582808
tremorAccAmpCoV 0.109337
tremorPcRelVar 0.767407
tremorPcX -0.0939147
tremorPcY 0.99558

ZigZag Offset Segment 1

Duration 28.72 s, Accuracy Estimate 0.05 (lower is better)

ZigZag Offset Segment 2

Duration 31.28 s, Accuracy Estimate 0.054 (lower is better)

ZigZag Offset Segment 3

Duration 30.4 s, Accuracy Estimate 0.034 (lower is better)

ZigZag Offset Segment 4

Duration 25.68 s, Accuracy Estimate 0.027 (lower is better)

ZigZag Offset Segment 5

Duration 23.72 s, Accuracy Estimate 0.048 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.75}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.64}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.6031257285812452}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8892396992576359}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5933514941667534}